Tributyrin (TB)meMonolaurin (GML), hei tāpiringa whāngai mahi, he maha ngā pānga ā-tinana o te pāmu heihei whāngai, e whakapai ake ana i te mahi whakaputa hua manu, te kounga hua manu, te hauora o te puku, me te pākia o te ngako. Kei raro nei ā rātou mahi matua me ngā tikanga:

1. Whakapai ake i te mahi whakaputa hua manu
Glycerol Monolaurate(GML)

Mā te tāpiri i te 0.15-0.45g/kg GML ki te kai a ngā heihei whāngai ka nui ake te tere o te whakaputa hua, ka whakaiti i te tere o te hurihanga kai, me te whakanui ake i te taumaha hua toharite.
E whakaatu ana tētahi rangahau ka taea e te 300-450mg/kg GML te whakapai ake i te tere whakaputa hua manu a ngā heihei whāngai me te whakaiti i te tere whakaputa hua hapa.

Tributyrin (TB) 

I roto i te whakamātautau o ngā heihei parai, ka taea e te 500mg/kg TB te whakaroa i te hekenga o te tere whakaputa hua i te wāhanga whakamutunga o te whānautanga hua, te whakapai ake i te kaha o te anga hua, me te whakaiti i te tere pao.
I honoa kiGML(pērā i te miraka kua patenttia) ka taea te whakaroa ake i te wā whakaputa hua manu me te whakapai ake i ngā painga ōhanga.

2. Whakapai ake i te kounga o te hua manu

Te mahi a te GML
Whakanuia te teitei o te pūmua, ngā waeine Haff (HU), me te whakarei ake i te tae o te toene.
Whakatikatikahia te hanganga waikawa ngako o te toene hua manu, whakanuia ake ngā waikawa ngako polyunsaturated (PUFA) me ngā waikawa ngako monounsaturated (MUFA), me te whakaiti i te nui o ngā waikawa ngako kukū (SFA).

I te horopeta o te 300mg/kg, i tino whakanuia e te GML te pakeke o te anga hua manu me te nui o te pūmua o te mā hua manu.

Te mahi aTB

Whakanuia te kaha o ngā anga hua manu, me te whakaiti i te tere o te pakaru o ngā anga (pēnei i te whakaiti i te 58.62-75.86% i roto i ngā whakamātautau).

Whakatairanga i te whakaaturanga o ngā ira e pā ana ki te whakatakotoranga konupūmā o te kōpū (pērā i te CAPB-D28K, OC17) me te whakapai ake i te whakapūngao o te anga hua manu.

3. Te whakahaere i te pākia o te ngako me te mahi antioxidant
Te mahi a te GML
Whakaitihia ngā triglycerides toto (TG), te cholesterol katoa (TC), me te cholesterol lipoprotein iti-kiato (LDL-C), ā, whakaitihia hoki te putunga ngako o te puku.
Whakapai ake i te mahi a te serum superoxide dismutase (SOD) me te glutathione peroxidase (GSH Px), whakaitihia te ihirangi o te malondialdehyde (MDA), me te whakarei ake i te kaha antioxidant.
Te mahi aTB
Whakaitihia te nui o te triglyceride i roto i te ate (10.2-34.23%) me te whakapiki ake i ngā ira e pā ana ki te waikura ngako (pērā i te CPT1).
Whakaitihia ngā taumata o te phosphatase kawakore (AKP) me te MDA i roto i te toto, ā, whakapiki ake i te kaha ārai mate katoa (T-AOC).

4. Whakapai ake i te hauora o te puku
Te mahi a te GML
Whakanuia te roa o te villus me te ōwehenga villus ki te villus (V/C) o te jejunum hei whakapai ake i te āhua o te puku.
Whakaitihia ngā āhuatanga mumura (pēnei i te IL-1 β, TNF - α), whakapiki ake i ngā āhuatanga ārai mumura (pēnei i te IL-4, IL-10), me te whakarei ake i te mahi ārai puku.
Whakapai ake i te hanganga o ngā moroiti cecal, whakaitihia te ōwehenga o ngā Proteobacteria, me te whakatairanga i te tipu o ngā huakita whai hua pēnei i a Spirogyraceae.
Te mahi a te TB
Whakatikatika i te pH o te puku, whakatairanga i te tipu o ngā huakita whai hua (pērā i te lactobacilli), me te aukati i ngā huakita kino.
Mā te whakanui ake i te whakapuakanga o te pūmua hononga piri (pērā i a Occludin, CLDN4) ka whakarei ake i te pumau o te ārai puku.

5. Te pānga whakahaere ārai mate
Te mahi a te GML
Whakapai ake i te taupū whēkau me te taupū thymus, whakarei ake i te mahi ārai mate.
Whakaitihia ngā tohu mumura toto pēnei i te aspartate aminotransferase (AST) me te alanine aminotransferase (ALT).
Te mahi a te TB
Whakaitihia te urupare mumura o te puku mā te whakahaere i te ara Toll like receptor (TLR2/4).

6. Pānga tono tahi
Kua whakaatuhia e ngā rangahau patent ka taea e te whakakotahitanga o te GML me te TB (pēnei i te 20-40 TB+15-30 GML) te whakapai ake i te tere whakaputa hua manu o ngā heihei whāngai (92.56% vs. 89.5%), te whakaiti i te mumura o ngā ngongo, me te whakaroa i te wā tino whakaputa hua manu.

Whakarāpopototanga:

Glycerol Monolaurate (GML)meTributyrin(TB)he pānga tautoko i roto i te mahi pāmu heihei:

GMLarotahi kite whakapai ake i te kounga o te hua manu, te whakahaere i te pākia o te ngako, me te mahi antioxidant;
TBarotahi kite whakapai ake i te hauora o te puku me te pākia o te konupūmā;
Ka taea e te huingaKa whai pānga tahi, ka whakapai ake i te mahi whakaputa me te kounga hua manu.