Kei te āta aukatia haeretia ngā momo hua paturopi i roto i te mahi heihei puta noa i te ao nā runga i ngā raruraru kino tae atu ki ngā toenga paturopi me te ātete ki ngā paturopi. Ko te Tributyrin tētahi atu huarahi pea hei whakakapi i ngā paturopi. I whakaatuhia e ngā hua o tēnei rangahau ka taea e te tributyrin te whakapai ake i te mahi tipu mā te whakarerekē i ngā tohu matū koiora toto me te hanganga microflora cecal o ngā heihei heihei huruhuru kōwhai. Ki tā mātou e mōhio ana, he iti noa ngā rangahau i rangahau i ngā pānga o te tributyrin ki ngā microbiota puku me tōna whanaungatanga ki te mahi tipu i roto i ngā heihei heihei heihei. Mā tēnei ka whakaratohia he pūtake pūtaiao mō te whakamahinga o te tributyrin i roto i te mahi ahuwhenua kararehe i tēnei wā whai muri i te paturopi.

Ka puta te waikawa pūmua i roto i te lumen o te puku kararehe mā te whakapūkara huakita o ngā warowaihā kai kāore anō kia nakunaku me ngā pūmua taketake. E 90% o tēnei waikawa pūmua ka whakapūkaratia e ngā pūtau epithelial cecal, e ngā colonocytes rānei, hei whakarato i ngā pānga pai maha ki te hauora o te puku.

Heoi, he kakara kino te waikawa pūmua kore utu, ā, he uaua ki te whakahaere i roto i te mahi. Hei tāpiri, kua whakaaturia ko ngā waikawa pūmua kore utu ka mimitihia i te ara puku o runga, ā, ko te mutunga iho kāore te nuinga e tae ki te whekau nui, te wāhi e mahi ai te waikawa pūmua i tana mahi matua.

Nō reira, kua whakawhanakehia te tote konutai butyrate arumoni hei whakahaere i te whakamahinga me te aukati i te tukunga o te waikawa butyric ki te ara puku o runga.

Engari ko te tributyrin he mea hanga mai i te waikawa butyric me te mono-butyrin, ā, i te ara puku o runga, ka whakawhēngia te tributyrin hei waikawa butyric me te α-mono-butyrin, engari i te puku o muri, ko te ngota matua ko te α-monobutyrin, e whakarato ana i te kaha ake, hei whakanui ake i te tipu o te uaua me te whakatairanga i te whanaketanga o ngā capillaries kia pai ake ai te kawe i ngā matūkai.

He maha ngā mate e pā ana ki te hauora o te puku o te heihei, tae atu ki:

• mate korere
• te mate mimiti koretake
• te mate kōkōtiō
• te mate puku necrotic

Kua whānuitia te whakamahinga o te tributyrin hei whawhai i ngā mate puku, ā, hei whakarei ake i te hauora o te puku heihei.

I roto i ngā heihei whāngai, ka taea e ia te whakapai ake i te mimiti o te konupūmā, inā koa i roto i ngā heihei whāngai tawhito, me te whakapai ake hoki i te kounga o te anga hua manu.

I roto i ngā poaka iti, he wā tino nui te whakawhiti i te kai ū nā te nui o te ahotea e puta mai ana i te neke mai i te kai wai ki te kai mārō, te rerekētanga o te taiao, me te whakaranu ki ngā hoa whare hou.

I roto i tētahi whakamātautau poaka i whakahaerehia i Rivalea, i kitea mārama ko te tāpiri i te 2.5 kg o ngā kai Tributyrin/MT i muri i te whakamutu i te ū mō ngā rā 35 i whakapai ake i te pikinga o te taumaha tinana mā te 5% me te ōwehenga hurihanga whāngai mā te 3 ngā piro.

Ka taea hoki te whakamahi i te Tributyrin i roto i te miraka hei whakakapi mō te miraka katoa, ā, ka whakakorea tētahi wāhanga o te pānga kino o ngā whakakapinga miraka ki te whanaketanga o te rumen.