Waikawa guanylacetic, e mōhiotia ana ko te waikawa guanylacetic, he waikawa amino rite i hangaia mai i te glycine me te L-lysine.

Ka taea e te waikawa guanylacetic te hanga i te creatine i raro i te whakaterenga a ngā whākōkī, ā, koinei anake te whakaritenga mō te hanga i te creatine. E mōhiotia ana te creatine hei parenga pūngao, ā, ko tana mahi matua ko te hanga i te creatine kua whakapūkawahia i raro i te mahi a te creatine kinase.

Whai wāhi atu ki te haerenga adenosinete huringa hosphate (ATP). Ina kore e ranea te kaha ATP, ka tere te whakawhiti a te phosphocreatine i te rōpū phosphate ki te adenosine diphosphate mā te creatine kinase ka huri anō ki te adenosine triphosphate.

 

Te tono i roto i ngā kararehe ruminant:

Mā te tāpiri i te waikawa guanylacetic 0.12%, 0.08%, me te 0.04% ki te kai a ngā hipi Tan 120 i whāngaihia ki te whare hipi, e 20 kirokaramu te taumaha, i whakaatuhia ko te tāpiritanga o te waikawa guanylacetic 0.12% me te 0.08% i tino whakanui i te taumaha o ia rā, te ngako uaua, me te nui o te pūmua, ā, i tino whakaiti i te nui o te ngako tinana.

 

Te tāpiri o te 0.08%waikawa guanylacetici piki ake te ōrau mīti kupenga mā te 9.77%. Mā te whakamahi i te tikanga whakaputa hau in vitro, i rangahauhia te pānga o te tāpiri i ngā taumata rerekē o te waikawa guanylacetic ki te rumen o ngā kau kōwhai. I kitea ko te tāpiri o te 0.4% waikawa guanylacetic i tino whakanui ake i te whakaputanga hau, ā, i piki ake te kukū o te hauota haukini i te tuatahi, kātahi ka heke iho.

Nō reira, ka taea te whakatau ko te tāpiri i te waikawa guanylacetic ki te whāngai o ia rā ka whakapai ake i te taiao o roto o te rumen me te aratau whakapūkara o te kau kōwhai.

Te tono i roto i te heihei:

Mā te tāpiri i te 800 mg/kg, 1600 mg/kg, 4000 mg/kg, me te 8000 mg/kg o te waikawa guanylacetic ki te whāngai o ia rā o ngā heihei parai, i kitea ai ko te tāpiri i te 800-4000 mg/kg o te waikawa guanylacetic ki te whāngai i tino whakanui ake i te taumaha o ia rā o ngā heihei parai, i whakaiti hoki i te ōwehenga whāngai ki te taumaha o ngā heihei parai i te 22-42 rā te pakeke. Mā te tāpiri i te 8000 mg/kg o te waikawa guanylacetic i whakapai ake i ngā tohu matū koiora o te toto pērā i te hauota urea, ngā tohu o te toto, me te bilirubin katoa. Kāore he pānga nui ki ngā tohu okana nui, e tohu ana he pai te tāpiri i te 8000 mg/kg o te waikawa guanylacetic ki te whāngai o ia rā o ngā heihei parai.

Mā te tāpiri i te 200 mg/kg, 400 mg/kg, 600 mg/kg, me te 800 mg/kg o te waikawa guanylacetic ki te whāngai heihei parai, i kitea he pikinga nui o te taumaha toharite o ia rā, ki te whakaritea ki te rōpū whakahaere. Ko ngā hua pai rawa atu i tutuki i te wā i tāpirihia ai ngā taumata 600 me te 800 mg/kg.

Hei ako i te pānga o te waikawa guanylacetic ki te kounga o te parāoa i roto i ngā heihei, e 20 ngā heihei 28 wiki te pakeke i tīpakohia hei whāngai i tētahi kai kei roto ko te 0%, 0.06%, 0.12%, me te 0.18% waikawa guanylacetic. I kitea i ngā hua rangahau ko te tāpiri i te 0.12% waikawa guanylacetic ki te kai i tino whakanui ake i te maha o ngā parāoa, te kukū o te parāoa, me te mahi parāoa i roto i ngā heihei, e tohu ana ko te tāpiri i te waikawa guanylacetic ki te kai ka taea te whakapai ake i te kounga o te parāoa. Tāpirihia te 0.0314%, 0.0628%, 0.0942%, me te 0.1256% waikawa guanylacetic ki te kai o ia rā o ngā heihei parai, ā, whakatakotoria kia rua ngā rōpū whakahaere (ko te rōpū whakahaere 1 he kai tipu kāore he matū i tāpirihia, ā, ko te rōpū whakahaere 2 he kai me te paraoa ika i tāpirihia). Ko ngā rōpū e ono o runga ake nei o ngā kai o ia rā he rite tonu te taumata o te pūngao me ngā kohuke.

E whakaatu ana ngā hua o te whakamātautau he teitei ake ngā reiti piki taumaha o ngā rōpū e whā i tāpirihia te waikawa guanylacetic me te rōpū whakahaere 2 i ērā o te rōpū whakahaere 1, Ko te rōpū whakahaere 2 te mea i pai ake te pānga piki taumaha, ā, whai muri ko te rōpū waikawa guanylacetic 0.0942%; Ko te rōpū whakahaere 2 te mea i pai ake te ōwehenga rauemi ki te taumaha, ā, whai muri ko te rōpū waikawa guanylacetic 0.1256%.

Te tono i roto i te heihei:

Tāpirihia te 800 mg/kg, 1600 mg/kg, 4000 mg/kg, me te 8000 mg/kg owaikawa guanylaceticI whakaatuhia i roto i te whāngai o ia rā mō ngā heihei parai, ko te tāpiri i te 800-4000 mg/kg o te waikawa guanylacetic ki te whāngai i tino whakanui ake i te taumaha o ia rā mō ngā heihei parai, ā, i whakaitihia te ōwehenga whāngai ki te taumaha o ngā heihei parai i te 22-42 rā te pakeke. I whakapai ake te tāpiri i te 8000 mg/kg o te waikawa guanylacetic i ngā tohu matū koiora o te toto pērā i te hauota urea, ngā tohu o te toto, me te bilirubin katoa. Kāore he pānga nui ki ngā tohu okana nui, e tohu ana he pai te tāpiri i te 8000 mg/kg o te waikawa guanylacetic ki te whāngai o ia rā mō ngā heihei parai. I whakaatuhia i roto i te tāpiri i te 200 mg/kg, 400 mg/kg, 600 mg/kg, me te 800 mg/kg o te waikawa guanylacetic ki te whāngai heihei parai he pikinga nui o te taumaha toharite o ia rā ki te whakataurite ki te rōpū whakahaere. Ko ngā hua pai rawa atu i tutuki i te wā i 600 me te 800 mg/kg ngā taumata tāpiri.

Hei ako i te pānga o te waikawa guanylacetic ki te kounga o te parāoa i roto i ngā heihei, e 20 ngā heihei 28 wiki te pakeke i tīpakohia hei whāngai i tētahi kai kei roto ko te 0%, 0.06%, 0.12%, me te 0.18% waikawa guanylacetic. I kitea i ngā hua rangahau ko te tāpiri i te 0.12% waikawa guanylacetic ki te kai i tino whakanui ake i te maha o ngā parāoa, te kukū o te parāoa, me te mahi parāoa i roto i ngā heihei, e tohu ana ko te tāpiri i te waikawa guanylacetic ki te kai ka taea te whakapai ake i te kounga o te parāoa. Tāpirihia te 0.0314%, 0.0628%, 0.0942%, me te 0.1256% waikawa guanylacetic ki te kai o ia rā o ngā heihei parai, ā, whakatakotoria kia rua ngā rōpū whakahaere (ko te rōpū whakahaere 1 he kai tipu kāore he matū i tāpirihia, ā, ko te rōpū whakahaere 2 he kai me te paraoa ika i tāpirihia). Ko ngā rōpū e ono o runga ake nei o ngā kai o ia rā he rite tonu te taumata o te pūngao me ngā kohuke. E whakaatu ana ngā hua o te whakamātautau he teitei ake ngā reiti pikinga taumaha o ngā rōpū e whā i tāpirihia te waikawa guanylacetic me te rōpū whakahaere 2 i ērā o te rōpū whakahaere 1. Ko te rōpū whakahaere 2 te mea i pai rawa te pānga pikinga taumaha, ā, i whai ake ko te 0.0942%.waikawa guanylaceticrōpū; Ko te rōpū whakahaere 2 te mea i pai rawa te ōwehenga rauemi ki te taumaha, ā, i whai ake ko te rōpū waikawa guanylacetic 0.1256%.