E hiahiatia ana ētahi atu rongoā hei whakakapi i ngā rongoā paturopi nā te mea kua aukatia te whakamahinga o ēnei rongoā hei whakatairanga tipu i roto i te whakatipu kararehe. Te āhua nei he mahi tā te Tributyrin ki te whakapai ake i te tipu o ngā poaka, ahakoa he rerekē te whai huatanga.

Tae noa mai ki tēnei wā, he iti noa iho ngā mōhiotanga mō ōna pānga ki te hanganga o ngā moroiti puku. I roto i tēnei rangahau, i tirotirohia e mātou ngā huringa o ngā moroiti puku o ngā poaka i whiwhi, i te wā e whakamutua ana te kai, i te 0.2% tributyrin i tāpirihia ki tā rātou kai taketake.

He nui ake te kaha o te rōpū Tributyrin mō te pākia o te pūngao, ā, he iti iho te kaha mō te pākia o te warowaihā. Hei whakamutunga, i whakaatu ā mātou hua ka taea e te tributyrin te whakatairanga i ngā huringa ki ngā hapori moroiti o te puku, ka taea hoki te whakapai ake i te mahi a te kararehe i muri i te whakamutu i te kai.

Ngā Pānga o te Tributyrin ki ngā Huringa o te Pūkahukahu e Pā Ana ki te Mahi a ngā Poaka e Whakamutua ana te Whakamutu Utu

Ngā Tawhā Hua

Ko te Tributyrin (e mōhiotia ana ko Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate) he momo ester waikawa ngako mekameka poto.

CAS RN: 60-01-5

Nama EINECS: 200-451-5

Tātai: C15H26O6

FW: 302.36

Āhua: He wai hinuhinu mā ki te kōwhai, he kakara ngako.

Wairewatanga: rewa i roto i te etanoru, te kōroporuma me te etera, he uaua ki te wairewa i roto i te wai (0.010%).

Te Ora o te Wāhi Pupuri: 24 Marama

Mōkihi: 25KG/ Pēke

Rokiroki: Hirihia ki ngā wāhi maroke, ā, he wāhi hauhautanga hoki

Tributyrinhe triglyceride kei roto e toru ngā ngota butyrate kua whakaesterihia hei glycerol, ka whakanui ake i ngā kukū butyrate i muri i te hydrolyzation e ngā lipases pancreatic.

Ngā Āhuatanga o te Tributyrin
He whakatupuranga hou o te butyrate-glycerol ester o te waikawa butyric.
100% karo i te puku.
Ko te tuku waikawa butyric ki roto i te whekau iti, kāore e hiahiatia kia pania.
Ka kitea noa i roto i te miraka me te honi.

Te Whakataurite i waenga i te Tote Tributyrin me te Tote Butyrate

E 6 meneti te haurua-ora o te waikawa butyric. He uaua ki te tae atu ki ētahi atu kiko me ngā whekau i waho o te whekau te Butyrate mēnā ka tukuna i roto i te ahua o te waikawa butyric, te butyrate rānei. Heoi, ko te haurua-ora o te tributyrin he 40 meneti, ā, ka taea te pupuri i te kukū plasma o te butyrate ki runga ake i te 0.1mM mō te 0.5-4 hāora mā te waha.

Tikanga me ngā Āhuatanga

Kaiwhakarato Pūngao

E mōhiotia whānuitia ana, ko te waikawa butyric he waikawa ngako mekameka poto, koinei te pūtake pūngao matua o ngā pūtau epithelial whekau. Neke atu i te 70% o te pūngao mō te tipu o ngā pūtau epithelial whekau e whakaratohia ana e te waikawa butyric. Heoi, ko te tributyrin te mea e whakarato ana i te uara waikawa butyric tino nui e tuku ana i te puku ki te whakataurite ki ētahi atu hua butyrate.

Te Tiaki i te Puku

►Ka whakatairanga a Tributyrin i te tipu me te wehewehe o ngā pūtau epithelial mucosal o te puku, ka whakatika i te mucosa kua pakaru, ā, ka whakawhānui i te mata hei mimiti i ngā matūkai.

►Ka whakatairanga a Tributyrin i te whakaaturanga o ngā pūmua hononga piripono i roto i te puku, ka pupuri i ngā hononga piripono i waenga i ngā pūtau, ka ārai i ngā macromolecules pēnei i te huakita me ngā paitini kei uru ki te tinana, ā, ka pupuri i te mahi ārai tinana o te puku.

►Ka whakatairanga a Tributyrin i te whakaputanga o te mucin (Muc) me te whakapakari i te mahi ārai matū o te puku.

Kua Whakapaitia te Auau Ora

Ka taea e te Tributyrin te whakatairanga i te hanga o te hemoglobin, te whakapai ake i te kaha ki te kawe hāora, te whakapakari i te pūnaha tautoko ora o roto, ā, ka taea hoki e ia te whakapai ake i te mahi a te mitochondria me te whakatairanga i te hanga o te ATP, te matū pūngao e akiaki ana i te mahi ora, kia pai ake ai te tere oranga o ngā kararehe.

Ārai-mumura me te ārai-huakita

►Mā te aukati i te mahi a NF-Kb, TNF-α me TLR, ka taea e Tributyrin te whakamama i te kino o te mumura.

►Ka whakatairanga a Tributyrin i te whakaputanga o ngā peptide parepare ā-roto, ka taea te ātete whānui ki ngā pathogen me ngā huaketo.