Tāpiringa whāngai: Tributyrin

Ihirangi: 95%, 90%

Ko te Tributyrin hei tāpiringa whāngai hei whakapai ake i te hauora o te puku o te manu.

Mā te whakamutua o ngā rongoā paturopi hei whakatairanga tipu i roto i ngā tohutao kai heihei kua piki ake te hiahia mō ngā rautaki kai rerekē, hei whakanui ake i te mahi a te heihei me te tiaki hoki i ngā mate pāwera.

Te whakaiti i te mamae o te dysbacteriosis
Hei ārai i ngā āhuatanga dysbacteriosis, kei te tāpirihia ngā tāpiringa kai pēnei i te probiotics me te prebiotics hei awe i te hanga o ngā SCFA, inā koa te waikawa butyric e whai wāhi nui ana ki te tiaki i te hanganga o te ara whekau. Ko te waikawa butyric he SCFA tūturu e puta ana i te taiao, he maha ngā pānga pai maha pērā i tōna pānga ārai-mumura, tōna awe ki te tere ake i te tukanga whakatika whekau me te whakaoho i te whanaketanga o ngā villi o te puku. He huarahi ahurei te mahi a te waikawa butyric mā te tikanga hei ārai i te mate, arā, ko te hanganga Host Defense Peptides (HDPs), e mōhiotia ana ko ngā peptides anti-microbial, he wāhanga nui o te ārai mate ā-roto. He whānui te mahi ārai-microbial ki ngā huakita, ngā harore, ngā pirinoa me ngā huaketo kua takaihia, he tino uaua ki ngā pathogens te whakawhanake i te ātete ki a rātou. Ko ngā Defensins (AvBD9 me AvBD14) me ngā Cathelicidins ngā whānau matua e rua o te HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) e kitea ana i roto i te heihei e whakanuia ana e te tāpiringa waikawa butyric. I roto i tētahi rangahau i whakahaerehia e Sunkara et. al. Mā te whakahaerenga o te waikawa butyric mai i waho ka nui ake te whakaaturanga ira HDP, ā, ka whakarei ake i te kaha ātete ki te mate i roto i ngā heihei. He mea whakamīharo, he iti noa iho ngā LCFA.

Ngā painga hauora o te Tributyrin
Ko te Tributyrin he matū mua o te waikawa butyric e āhei ai te tuku tika atu i ngā ngota ngota o te waikawa butyric ki roto i te whekau iti nā te tikanga esterification. Nō reira, e rua, e toru rānei ngā wā teitei ake o ngā kukū i ngā hua pania noa. Mā te esterification ka taea te here i ngā ngota ngota waikawa butyric e toru ki te glycerol, ā, mā te lipase pancreatic taketake anake ka pakaru.
I whakatūria e Li me ētahi atu tētahi rangahau ārai mate hei kimi i ngā pānga pai o te tributyrin ki ngā cytokine mumura i roto i ngā heihei heihei i werohia ki te LPS (lipopolysaccharide). E mōhiotia whānuitia ana te whakamahinga o te LPS hei whakaoho i te mumura i roto i ngā rangahau pēnei i tēnei nā te mea ka whakahohe i ngā tohu mumura pēnei i te IL (Interleukins). I ngā rā 22, 24, me te 26 o te whakamātautau, i werohia ngā heihei heihei ki te whakahaerenga intraperitoneal o te 500 μg/kg BW LPS, te saline rānei. Ko te tāpiringa tributyrin kai o te 500 mg/kg i aukati i te pikinga o te IL-1β me te IL-6 e kī ana ka taea e tana tāpiringa te whakaiti i te tukunga o ngā cytokine mumura, ā, nā reira ka whakaiti i te mumura o te puku.

Whakarāpopototanga
I te mea kua whakawhāitihia te whakamahinga, kua aukatia katoatia rānei ētahi kaiwhakatairanga tipu paturopi hei tāpiringa whāngai, me tūhuratia ngā rautaki hou hei whakapai ake me te tiaki i te hauora o ngā kararehe pāmu. Ko te āhua o te puku he hononga nui i waenga i ngā rauemi mata kai utu nui me te whakatairanga tipu i roto i ngā heihei tunu kai. Ko te waikawa butyric, inā koa, e mōhiotia ana he kaha ki te whakatairanga i te hauora o te puku kua whakamahia kētia i roto i te whāngai kararehe mō ngā tau neke atu i te 20. Ka tukuna e te Tributyrin te waikawa butyric ki roto i te puku iti, ā, he tino whai hua ki te pā ki te hauora o te puku mā te tere ake i te tukanga whakatika puku, te whakatenatena i te whanaketanga pai o ngā villi me te whakarerekē i ngā tauhohenga ārai mate i roto i te ara puku.

I te mea kua whakamutua te whakamahi i ngā paturopi, he taputapu pai te waikawa butyric hei tautoko i te umanga ki te whakaiti i ngā pānga kino o te dysbacteriosis e puta ake ana hei hua o tēnei huringa.